{"id":223971,"date":"2024-09-06T21:44:11","date_gmt":"2024-09-06T19:44:11","guid":{"rendered":"https:\/\/alanwaralmsreah.com\/?p=223971"},"modified":"2024-09-06T21:44:11","modified_gmt":"2024-09-06T19:44:11","slug":"%d8%b5%d9%86%d8%a7%d8%b9%d8%a9-%d8%a7%d9%84%d8%aa%d9%83%d9%86%d9%88%d9%84%d9%88%d8%ac%d9%8a%d8%a7","status":"publish","type":"post","link":"https:\/\/alanwaralmsreah.com\/?p=223971","title":{"rendered":"\u0633\u0628\u0639 \u0634\u0631\u0643\u0627\u062a \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u062a\u062d\u0648\u064a\u0644 \u0635\u0646\u0627\u0639\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0625\u064a\u0637\u0627\u0644\u064a\u0627"},"content":{"rendered":"
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\n
\u062a\u0634\u062a\u0647\u0631 \u0625\u064a\u0637\u0627\u0644\u064a\u0627 \u0628\u0647\u0646\u062f\u0633\u062a\u0647\u0627 \u0627\u0644\u0645\u0639\u0645\u0627\u0631\u064a\u0629 \u0648\u0645\u0623\u0643\u0648\u0644\u0627\u062a\u0647\u0627 \u0648\u0641\u0646\u0648\u0646\u0647\u0627 \u0648\u0623\u0632\u064a\u0627\u0626\u0647\u0627\u060c \u0648\u0647\u064a \u0644\u0627\u0639\u0628 \u0628\u0627\u0631\u0632 \u0641\u064a \u0635\u0646\u0627\u0639\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0645\u0639 \u0635\u0646\u0627\u0639\u0629 \u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u062d\u064a\u0648\u064a\u0629 \u062b\u0627\u0628\u062a\u0629 \u0648\u0639\u062f\u062f \u0645\u062a\u0632\u0627\u064a\u062f \u0645\u0646 \u0627\u0644\u0634\u0631\u0643\u0627\u062a.<\/strong><\/div>\n<\/div>\n
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\u0623\u0643\u062b\u0631 \u0645\u0646 90% \u0645\u0646 \u0625\u064a\u0631\u0627\u062f\u0627\u062a \u0635\u0646\u0627\u0639\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u062a\u0623\u062a\u064a \u0645\u0646 \u0645\u0646\u0627\u0637\u0642 \u0644\u0648\u0645\u0628\u0627\u0631\u062f\u064a \u0648\u0644\u0627\u062a\u0633\u064a\u0648 \u0648\u062a\u0648\u0633\u0643\u0627\u0646\u0627 \u0648\u0628\u064a\u064a\u0645\u0648\u0646\u062a\u064a. \u0627\u0639\u062a\u0628\u0627\u0631\u064b\u0627 \u0645\u0646 \u0639\u0627\u0645 2023\u060c \u062a\u062a\u0643\u0648\u0646 \u0635\u0646\u0627\u0639\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0625\u064a\u0637\u0627\u0644\u064a\u0629 \u0645\u0646 \u0623\u0643\u062b\u0631 \u0645\u0646 800 \u0634\u0631\u0643\u0629\u060c \u062a\u0648\u0638\u0641 \u062d\u0648\u0627\u0644\u064a 13700 \u0634\u062e\u0635\u060c \u0648\u062a\u0648\u0644\u062f \u0623\u0643\u062b\u0631 \u0645\u0646 13 \u0645\u0644\u064a\u0627\u0631 \u064a\u0648\u0631\u0648 \u0641\u064a \u062d\u062c\u0645 \u0627\u0644\u0623\u0639\u0645\u0627\u0644.<\/strong><\/div>\n<\/div>\n
\n
\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629\u060c \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u062a\u0648\u0633\u0639 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0632\u0631\u0627\u0639\u0629 \u0648\u0627\u0644\u0627\u0633\u062a\u062f\u0627\u0645\u0629 \u0627\u0644\u0628\u064a\u0626\u064a\u0629 \u0648\u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0635\u0646\u0627\u0639\u064a\u0629. \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0627\u0644\u0627\u062a \u0646\u0645\u0648\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627\u060c \u062e\u0627\u0635\u0629 \u0641\u064a \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0642\u0644\u064a\u0644\u0629 \u0627\u0644\u0645\u0627\u0636\u064a\u0629\u060c \u062d\u064a\u062b \u0634\u0647\u062f\u062a \u0628\u0639\u0636 \u0627\u0644\u0642\u0637\u0627\u0639\u0627\u062a \u0645\u0639\u062f\u0644\u0627\u062a \u0646\u0645\u0648 \u062a\u062c\u0627\u0648\u0632\u062a 30%.<\/strong><\/div>\n
\u0623\u0641\u0627\u0646\u063a\u0627\u0631\u062f \u0628\u0648<\/strong><\/div>\n
\u0623\u0641\u0627\u0646\u063a\u0627\u0631\u062f \u0628\u0648 AAVantgarde Bio\u060c \u0627\u0644\u062a\u064a \u062a\u062a\u062e\u0630 \u0645\u0646 \u0645\u064a\u0644\u0627\u0646\u0648 \u0628\u0625\u064a\u0637\u0627\u0644\u064a\u0627 \u0645\u0642\u0631\u0627\u064b \u0644\u0647\u0627\u060c \u0647\u064a \u0634\u0631\u0643\u0629 \u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u062d\u064a\u0648\u064a\u0629 \u062a\u0631\u0643\u0632 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629\u060c \u0648\u062a\u0633\u062a\u0647\u062f\u0641 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629. \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0624\u062f\u064a \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0627\u062a\u060c \u0627\u0644\u062a\u064a \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u0643\u0648\u0646 \u0648\u0631\u0627\u062b\u064a\u0629\u060c \u0625\u0644\u0649 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0628\u0635\u0631 \u0627\u0644\u062a\u062f\u0631\u064a\u062c\u064a \u0623\u0648 \u0627\u0644\u0639\u0645\u0649 \u0627\u0644\u0643\u0627\u0645\u0644.<\/strong><\/div>\n<\/div>\n
\n
\u0644\u0645\u0627\u0630\u0627 \u0627\u0644\u062d\u0631\u0641 A \u0627\u0644\u0645\u0632\u062f\u0648\u062c \u0641\u064a AAVantgarde Bio\u061f \u062d\u0633\u0646\u064b\u0627\u060c \u0628\u0628\u0633\u0627\u0637\u0629 \u0644\u0623\u0646 \u0627\u0644\u0646\u0647\u062c \u0627\u0644\u0639\u0644\u0645\u064a \u0627\u0644\u0623\u0633\u0627\u0633\u064a \u0644\u0644\u0634\u0631\u0643\u0629 \u064a\u062a\u0636\u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0627\u0642\u0644\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u063a\u062f\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 (AAV). \u0647\u0630\u0647 \u0627\u0644\u0646\u0648\u0627\u0642\u0644 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u0639\u062f\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u062a\u0646\u0642\u0644 \u0646\u0633\u062e\u064b\u0627 \u0648\u0638\u064a\u0641\u064a\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0631\u064a\u0636. \u062a\u0633\u062a\u0641\u064a\u062f \u0627\u0644\u0634\u0631\u0643\u0629 \u0645\u0646 \u0646\u0627\u0642\u0644\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u063a\u062f\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0647\u0630\u0647 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0648\u062a\u0635\u062d\u064a\u062d \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0639\u064a\u0628\u0629 \u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0644\u0648\u0642\u0641 \u0623\u0648 \u062d\u062a\u0649 \u0639\u0643\u0633 \u062a\u0642\u062f\u0645 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0628\u0635\u0631.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u0639\u062f \u0646\u0627\u0642\u0644\u0627\u062a AAV \u0645\u0646\u0627\u0633\u0628\u0629 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0646\u0638\u0631\u064b\u0627 \u0644\u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u062d\u0648\u064a\u0644 \u0628\u0643\u0641\u0627\u0621\u0629\u060c \u0623\u064a \u0625\u062f\u062e\u0627\u0644 \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629\u060c \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0645\u0639 \u0627\u0644\u062d\u062f \u0627\u0644\u0623\u062f\u0646\u0649 \u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u0623\u062f\u0627\u0629 \u0648\u0627\u0639\u062f\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f.<\/strong><\/div>\n<\/div>\n
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\u062a\u0639\u0645\u0644 AAVantgarde Bio \u062d\u0627\u0644\u064a\u064b\u0627 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u062e\u0637 \u0623\u0646\u0627\u0628\u064a\u0628 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629. \u064a\u0631\u0643\u0632 \u0627\u0644\u0645\u0631\u0634\u062d \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0642\u062f\u0645\u064b\u0627 \u0644\u0644\u0634\u0631\u0643\u0629\u060c AAVB-081\u060c \u0639\u0644\u0649 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0622\u0634\u0631 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1\u060c \u0648\u0627\u0644\u062a\u064a \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u062a\u0645\u064a\u0632 \u0628\u0627\u0644\u0639\u0645\u0649 \u0627\u0644\u0644\u064a\u0644\u064a \u0645\u062a\u0628\u0648\u0639\u064b\u0627 \u0628\u062a\u062f\u0647\u0648\u0631 \u062a\u062f\u0631\u064a\u062c\u064a \u0644\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u0637\u0631\u0641\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u0641\u064a \u0627\u0644\u0639\u0627\u0645 \u0627\u0644\u0645\u0627\u0636\u064a\u060c \u0623\u0643\u0645\u0644\u062a \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0625\u064a\u0637\u0627\u0644\u064a\u0629 \u062c\u0648\u0644\u0629 \u062a\u0645\u0648\u064a\u0644 \u0645\u0646 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 A\u060c \u062d\u064a\u062b \u062c\u0645\u0639\u062a 67.7 \u0645\u0644\u064a\u0648\u0646 \u062f\u0648\u0644\u0627\u0631.<\/strong><\/div>\n<\/div>\n
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\u0639\u0644\u064a\u0627\u0621 \u062b\u064a\u0631\u0627\u0628\u064a\u0648\u062a\u0643\u0633 Alia Therapeutics<\/strong><\/div>\n
\u062a\u0623\u0633\u0633\u062a \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0625\u064a\u0637\u0627\u0644\u064a\u0629 \u0641\u064a \u0639\u0627\u0645 2018 \u0643\u0634\u0631\u0643\u0629 \u0641\u0631\u0639\u064a\u0629 \u0645\u0646 \u062c\u0627\u0645\u0639\u0629 \u062a\u0631\u064a\u0646\u062a\u0648\u060c \u0648\u0647\u064a \u0645\u0643\u0631\u0633\u0629 \u0644\u0625\u0646\u0634\u0627\u0621 \u0639\u0644\u0627\u062c\u0627\u062a \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u0646\u0627\u062f\u0631\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0623\u0646\u0638\u0645\u0629 CRISPR-Cas \u0644\u062a\u0635\u062d\u064a\u062d \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0639\u0646\u062f \u0645\u0635\u062f\u0631\u0647\u0627.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u0631\u0643\u0632 \u0634\u0631\u0643\u0629 Alia Therapeutics \u0639\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u062e\u0635\u0648\u0635\u064a\u0629 \u0648\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 CRISPR\u060c \u0648\u062e\u0627\u0635\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0637\u0648\u064a\u0631 \u0645\u062a\u063a\u064a\u0631\u0627\u062a Cas9 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u062d\u062f\u064a\u062f. \u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0647\u0630\u0647 \u0627\u0644\u0625\u0635\u062f\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u0633\u0646\u0629 \u0645\u0646 \u0646\u0638\u0627\u0645 CRISPR-Cas \u0644\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0634\u0643\u0644 \u0645\u0635\u062f\u0631 \u0642\u0644\u0642 \u0643\u0628\u064a\u0631 \u0641\u064a \u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a.<\/strong><\/div>\n<\/div>\n
\n
\u064a\u0647\u062f\u0641 \u0645\u0631\u0634\u062d\u0647\u0627 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0625\u0644\u0649 \u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a \u0627\u0644\u0633\u0627\u0626\u062f (ADRP)\u060c \u0648\u0647\u0648 \u0627\u0636\u0637\u0631\u0627\u0628 \u0648\u0631\u0627\u062b\u064a \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646. \u0625\u0646\u0647 \u0623\u062d\u062f \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a (RP)\u060c \u0648\u0647\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u062a\u062f\u0631\u064a\u062c\u064a \u0628\u0633\u0628\u0628 \u062a\u0646\u0643\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0629 \u0644\u0644\u0636\u0648\u0621 \u0641\u064a \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646.<\/strong><\/div>\n<\/div>\n
\n
\u0641\u064a \u0639\u0627\u0645 2023\u060c \u062d\u0635\u0644\u062a \u0634\u0631\u0643\u0629 \u0639\u0644\u064a\u0627\u0621 \u062b\u064a\u0631\u0627\u0628\u064a\u0648\u062a\u0643\u0633 \u0639\u0644\u0649 4.9 \u0645\u0644\u064a\u0648\u0646 \u062f\u0648\u0644\u0627\u0631 \u0641\u064a \u062a\u0645\u0648\u064a\u0644 \u0623\u0648\u0644\u064a\u060c \u0628\u0642\u064a\u0627\u062f\u0629 Sofinnova Partners. \u0633\u064a\u062f\u0639\u0645 \u0647\u0630\u0627 \u0627\u0644\u062a\u0645\u0648\u064a\u0644 \u062a\u0637\u0648\u064a\u0631 \u0645\u0646\u0635\u0629 CRISPR \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0627 \u0648\u062a\u0642\u062f\u0645 \u0645\u0631\u0634\u062d\u0647\u0627 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0646\u062d\u0648 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u0643\u0648\u0646\u062a\u0631\u0627\u0631\u064a\u0627 \u0644\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 Contraria Biotech<\/strong><\/div>\n
\u062a\u0645 \u062a\u0648\u062b\u064a\u0642 \u0645\u0641\u0647\u0648\u0645 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0639\u0643\u0633\u064a\u0629 \u0645\u0646\u0630 \u0627\u0644\u062a\u0633\u0639\u064a\u0646\u064a\u0627\u062a. \u0628\u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0645\u0628\u062f\u0623 \u0627\u0644\u0627\u0633\u062a\u0646\u0633\u0627\u062e \u0648\u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a \u0641\u064a \u062a\u0633\u0644\u0633\u0644 \u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0643\u0627\u0626\u0646 \u0627\u0644\u062d\u064a\u060c \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0647 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0641\u064a \u0625\u0646\u0634\u0627\u0621 \u0644\u0642\u0627\u062d \u0636\u062f \u0627\u0644\u0645\u0643\u0648\u0631\u0627\u062a \u0627\u0644\u0633\u062d\u0627\u0626\u064a\u0629 – \u0648\u0647\u064a \u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u062a\u0633\u0628\u0628 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0633\u062d\u0627\u064a\u0627. \u0627\u0644\u0622\u0646\u060c \u062a\u0633\u062a\u062e\u062f\u0645 \u0634\u0631\u0643\u0629 Contraria\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0628\u0627\u0633\u0645 Achilles Vaccines\u060c \u0647\u0630\u0647 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0644\u0642\u0627\u062d\u0627\u062a \u0636\u062f \u0627\u0644\u0645\u0644\u0627\u0631\u064a\u0627.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u0633\u062a\u0641\u064a\u062f \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0642\u0639 \u0641\u064a “\u0645\u0631\u0643\u0632 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a” \u0641\u064a \u0633\u064a\u064a\u0646\u0627 \u0641\u064a \u0625\u064a\u0637\u0627\u0644\u064a\u0627\u060c \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u0630\u0643\u0627\u0621 \u0627\u0644\u0627\u0635\u0637\u0646\u0627\u0639\u064a \u0641\u064a \u0645\u0646\u0635\u0629 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0639\u0643\u0633\u064a\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062a\u0627\u0644\u064a (NGRV). \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0639\u0645\u0644 \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0644\u0642\u0627\u062d\u0627\u062a \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0627\u0631\u062c\u064a \u0627\u0644\u0645\u0639\u062f\u0644\u0629 (mOMV). \u062a\u062d\u062a\u0648\u064a \u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0627\u0631\u062c\u064a (OMV) \u0639\u0644\u0649 \u0641\u0633\u0641\u0648\u0644\u064a\u0628\u064a\u062f\u0627\u062a\u060c \u0648\u0633\u0643\u0631\u064a\u0627\u062a \u0644\u064a\u0628\u0648\u0628\u0648\u0644\u064a\u060c \u0648\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u060c \u0648\u0645\u0643\u0648\u0646\u0627\u062a \u0645\u062d\u064a\u0637\u064a\u0629 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0648\u0642\u062f \u0623\u062b\u0628\u062a\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u0644\u0642\u0627\u062d\u0627\u062a \u0641\u064a \u0646\u0645\u0627\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0648\u0628\u0634\u0631\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u0639\u0645\u0644 \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u0631\u0634\u062d\u064a\u0646 \u0641\u064a \u062e\u0637 \u0623\u0646\u0627\u0628\u064a\u0628\u0647\u0627. \u0648\u0645\u0646 \u0628\u064a\u0646\u0647\u0627 \u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0644\u0627\u0631\u064a\u0627\u060c \u0627\u0644\u0630\u064a \u062d\u0638\u064a \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u0648\u062a\u0645\u0648\u064a\u0644 \u0643\u0628\u064a\u0631\u064a\u0646\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 12.2 \u0645\u0644\u064a\u0648\u0646 \u062f\u0648\u0644\u0627\u0631 \u0645\u0646 \u0635\u0646\u062f\u0648\u0642 \u0627\u0644\u0645\u0644\u0627\u0631\u064a\u0627 \u0627\u0644\u062a\u0627\u0628\u0639 \u0644\u0644\u0627\u062a\u062d\u0627\u062f \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a. \u0635\u0646\u062f\u0648\u0642 \u0631\u064a\u0627. \u0645\u0631\u0634\u062d \u0628\u0627\u0631\u0632 \u0622\u062e\u0631 \u0647\u0648 MAbCo19\u060c \u0648\u0647\u0648 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u0648\u062d\u064a\u062f \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u062a\u0645 \u062a\u0637\u0648\u064a\u0631\u0647 \u0644\u0645\u0643\u0627\u0641\u062d\u0629 SARS-CoV-2\u060c \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0645\u0631\u0636 \u0643\u0648\u0641\u064a\u062f-19. \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u0644\u0627\u0635 \u0647\u0630\u0627 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u0636\u0627\u062f \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u0645\u062a\u0639\u0627\u0641\u064a\u0646\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631\u0647\u0627 \u0644\u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0645\u062d\u0627\u064a\u062f\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u062c\u064a\u0646\u064a\u0646\u062a\u0627 \u0633\u0627\u064a\u0646\u0633<\/strong><\/div>\n
\u062a\u0623\u0633\u0633\u062a \u062c\u064a\u0646\u064a\u0646\u062a\u0627 \u0633\u0627\u064a\u0646\u0633 \u0641\u064a \u0639\u0627\u0645 2014 \u0648\u0645\u0642\u0631\u0647\u0627 \u0645\u064a\u0644\u0627\u0646\u0648 \u0628\u0625\u064a\u0637\u0627\u0644\u064a\u0627\u060c \u0648\u0647\u064a \u0634\u0631\u0643\u0629 \u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u062a\u062e\u0635\u0635\u0629 \u0641\u064a \u0639\u0644\u0645 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u0646\u0627\u0639\u064a. \u0627\u0644\u0634\u0631\u0643\u0629 \u0631\u0627\u0626\u062f\u0629 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 \u0645\u0646\u0635\u0629 \u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u0633\u062a\u0641\u064a\u062f \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u062f\u0645 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0635\u0644\u0628\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u064a\u062a\u0636\u0645\u0646 \u0646\u0647\u062c \u062c\u064a\u0646\u064a\u0646\u062a\u0627 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u062f\u0645 \u0627\u0644\u0630\u0627\u062a\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0644\u0641\u064a\u0629 (HSPCs) \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u062e\u0627\u0631\u062c \u0627\u0644\u062c\u0633\u0645 \u0644\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0625\u0646\u062a\u0631\u0641\u064a\u0631\u0648\u0646 \u0623\u0644\u0641\u0627 (IFN-\u03b1) \u062a\u062d\u062a \u0633\u064a\u0637\u0631\u0629 \u0627\u0644\u0645\u062d\u0641\u0632\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0648\u0631\u0645. \u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0644\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u0628\u064a\u0626\u0629 \u0627\u0644\u0648\u0631\u0645 \u0648\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0639\u062f\u0644 \u0644\u0644\u0645\u0646\u0627\u0639\u0629 \u0645\u0628\u0627\u0634\u0631\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0648\u0631\u0645\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062c\u0646\u0628 \u0627\u0644\u0633\u0645\u064a\u0629 \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0639\u0627\u062f\u0629 \u0628\u0639\u0644\u0627\u062c IFN-\u03b1. \u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641 \u0625\u0644\u0649 \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0636\u062f \u0627\u0644\u0648\u0631\u0645 \u0645\u0639 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u0636\u0627\u0631\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u0627\u0644\u0645\u0646\u062a\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0634\u0631\u0643\u0629\u060c Temferon\u060c \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 1\/2 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0623\u0631\u0648\u0645\u064a \u0627\u0644\u062f\u0628\u0642\u064a \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 (GBM)\u060c \u0648\u0647\u0648 \u0648\u0631\u0645 \u062f\u0645\u0627\u063a\u064a \u0634\u062f\u064a\u062f \u0627\u0644\u0639\u062f\u0648\u0627\u0646\u064a\u0629 \u0645\u0639 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c \u0645\u062d\u062f\u0648\u062f\u0629. \u0623\u0638\u0647\u0631 Temferon \u0646\u062a\u0627\u0626\u062c \u0623\u0648\u0644\u064a\u0629 \u0648\u0627\u0639\u062f\u0629\u060c \u0645\u0639 \u0639\u062f\u0645 \u0645\u0644\u0627\u062d\u0638\u0629 \u0623\u064a \u0633\u0645\u064a\u0629 \u062a\u062d\u062f \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646\u060c \u0648\u062f\u0644\u064a\u0644 \u0639\u0644\u0649 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u062f\u0627\u062e\u0644 \u0628\u064a\u0626\u0629 \u0627\u0644\u0648\u0631\u0645.<\/strong><\/div>\n<\/div>\n
\n
\u0641\u064a \u0639\u0627\u0645 2024\u060c \u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Genenta \u0623\u0646\u0647\u0627 \u0642\u0627\u0645\u062a \u0628\u0642\u064a\u0627\u0633 \u0627\u0644\u062c\u0631\u0639\u0629 \u0644\u0623\u0648\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0645\u0646 \u062a\u062c\u0631\u0628\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0623\u0631\u0648\u0645\u064a \u0627\u0644\u062f\u0628\u0642\u064a \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644\u060c \u0648\u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0625\u0644\u0649 \u0641\u0627\u0626\u062f\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0644\u062f\u0649 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649. \u0648\u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0648\u0633\u0639\u062a \u0634\u0631\u0643\u0629 Genenta \u062a\u0631\u0643\u064a\u0632\u0647\u0627 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0644\u064a\u0634\u0645\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0644\u0648\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u0643\u064a\u062b\u0631 \u0628\u064a\u0648\u062a\u064a\u0643<\/strong><\/div>\n
\u062a\u062a\u062e\u0635\u0635 \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u062e\u0630 \u0645\u0646 \u062a\u0648\u0631\u064a\u0646\u0648 \u0645\u0642\u0631\u0627\u064b \u0644\u0647\u0627 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629\u060c \u0648\u062e\u0627\u0635\u0629 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0645\u062b\u0644 \u0627\u0644\u0631\u0628\u0648 \u0648\u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0645\u0632\u0645\u0646. \u0648\u064a\u062a\u0645\u062b\u0644 \u0646\u0647\u062c \u0627\u0644\u0634\u0631\u0643\u0629 \u0641\u064a \u062a\u0639\u062f\u064a\u0644 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0634\u0627\u0631\u0643 \u0641\u064a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0628\u0647\u062f\u0641 \u062a\u0648\u0641\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0627\u0633\u062a\u0647\u062f\u0627\u0641\u064b\u0627.<\/strong><\/div>\n<\/div>\n
\n
\u0648\u0628\u0634\u0643\u0644 \u0623\u0643\u062b\u0631 \u062a\u062d\u062f\u064a\u062f\u064b\u0627\u060c \u064a\u0631\u0643\u0632 \u0643\u064a\u062b\u0631 \u0639\u0644\u0649 \u062a\u0639\u062f\u064a\u0644 \u0645\u0633\u0627\u0631 \u0641\u0648\u0633\u0641\u0648\u0625\u064a\u0646\u0648\u0632\u064a\u062a\u064a\u062f 3-\u0643\u064a\u0646\u0627\u0632 (PI3K)\u060c \u0648\u0647\u0648 \u0645\u0633\u0627\u0631 \u0625\u0634\u0627\u0631\u0627\u062a \u064a\u0634\u0627\u0631\u0643 \u0641\u064a \u0646\u0645\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0646\u062a\u0634\u0627\u0631\u0647\u0627 \u0648\u0628\u0642\u0627\u0626\u0647\u0627. \u0648\u064a\u0631\u062a\u0628\u0637 \u062e\u0644\u0644 \u062a\u0646\u0638\u064a\u0645 \u0647\u0630\u0627 \u0627\u0644\u0645\u0633\u0627\u0631 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0631\u0628\u0648 \u0648\u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0645\u0632\u0645\u0646. \u0648\u064a\u062a\u0636\u0645\u0646 \u0646\u0647\u062c \u0643\u064a\u062b\u0631 \u062a\u0637\u0648\u064a\u0631 \u0645\u062b\u0628\u0637\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0643\u0648\u0646\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0645\u0646 \u0645\u0633\u0627\u0631 PI3K\u060c \u0628\u0647\u062f\u0641 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u062a\u062d\u0633\u064a\u0646 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u062a\u0631\u0643\u0632 \u0645\u0646\u0635\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0631\u0627\u0626\u062f\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0627 \u062d\u0648\u0644 \u062a\u062b\u0628\u064a\u0637 PI3K gamma (PI3K\u03b3)\u060c \u0648\u0647\u0648 \u0634\u0643\u0644 \u0645\u062d\u062f\u062f \u0645\u0646 \u0625\u0646\u0632\u064a\u0645 PI3K \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u064b\u0627 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0631\u0626\u062a\u064a\u0646. \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062b\u0628\u064a\u0637 PI3K\u03b3 \u0628\u0634\u0643\u0644 \u0627\u0646\u062a\u0642\u0627\u0626\u064a\u060c \u062a\u0647\u062f\u0641 \u0634\u0631\u0643\u0629 Kither Biotech \u0625\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0632\u0645\u0646 \u062f\u0648\u0646 \u0627\u0644\u0645\u0633\u0627\u0633 \u0628\u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u062f\u0648\u0649.<\/strong><\/div>\n<\/div>\n
\n
\u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0645\u0631\u0634\u062d \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0625\u064a\u0637\u0627\u0644\u064a\u0629\u060c KIT2014\u060c \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0644\u064a\u0641 \u0627\u0644\u0643\u064a\u0633\u064a (CF). \u0623\u0638\u0647\u0631 KIT2014 \u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0639\u062f\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u062d\u064a\u062b \u0623\u062b\u0628\u062a \u0642\u062f\u0631\u062a\u0647 \u0639\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0645\u0633\u062a\u0648\u064a\u0627\u062a cAMP \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0631\u0626\u0648\u064a\u0629. \u062a\u0639\u0645\u0644 \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 KIT2014 \u0646\u062d\u0648 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0645\u0639 \u062e\u0637\u0637 \u0644\u062a\u0642\u064a\u064a\u0645 \u0633\u0644\u0627\u0645\u062a\u0647 \u0648\u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 \u0627\u0644\u0628\u0634\u0631.<\/strong><\/div>\n<\/div>\n
\n
\u0641\u064a \u0639\u0627\u0645 2022\u060c \u0623\u0643\u0645\u0644\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u062c\u0648\u0644\u0629 \u062a\u0645\u0648\u064a\u0644 \u0645\u0646 \u0627\u0644\u0641\u0626\u0629 B \u0628\u0642\u064a\u0645\u0629 20.5 \u0645\u0644\u064a\u0648\u0646 \u062f\u0648\u0644\u0627\u0631.<\/strong><\/div>\n<\/div>\n
\n
\u0631\u064a\u0633\u0627\u0644\u064a\u0633 \u062b\u064a\u0631\u0627\u0628\u064a\u0648\u062a\u064a\u0643\u0633 Resalis Therapeutics<\/strong><\/div>\n
\u062a\u0631\u0643\u0632 \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0625\u064a\u0637\u0627\u0644\u064a\u0629 \u0639\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u063a\u064a\u0631 \u0627\u0644\u0645\u0634\u0641\u0631 (ncRNA). \u062a\u0631\u0643\u0632 \u062c\u0647\u0648\u062f \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0644\u0644\u0634\u0631\u0643\u0629 \u0639\u0644\u0649 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0623\u064a\u0636\u064a\u0629\u060c \u0645\u062b\u0644 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u062f\u0647\u0646\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0623\u064a\u0636 (MASH)\u060c \u0648\u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646.<\/strong><\/div>\n<\/div>\n
\n
\u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u0643\u0648\u0646 MASH \u0628\u062f\u0648\u0646 \u0623\u0639\u0631\u0627\u0636 \u0641\u064a \u0645\u0631\u0627\u062d\u0644\u0647 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644 \u062a\u0634\u062e\u064a\u0635\u0647 \u0635\u0639\u0628\u064b\u0627 \u062d\u062a\u0649 \u064a\u062a\u0642\u062f\u0645. \u0639\u0646\u062f\u0645\u0627 \u062a\u0638\u0647\u0631 \u0627\u0644\u0623\u0639\u0631\u0627\u0636\u060c \u0641\u0642\u062f \u062a\u0634\u0645\u0644 \u0627\u0644\u062a\u0639\u0628 \u0648\u0627\u0644\u0636\u0639\u0641 \u0648\u0639\u062f\u0645 \u0627\u0644\u0631\u0627\u062d\u0629 \u0641\u064a \u0627\u0644\u0628\u0637\u0646 \u0648\u0639\u0644\u0627\u0645\u0627\u062a \u062e\u0644\u0644 \u0641\u064a \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0643\u0628\u062f. \u0625\u0630\u0627 \u062a\u064f\u0631\u0650\u0643 \u062f\u0648\u0646 \u0639\u0644\u0627\u062c\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u0637\u0648\u0631 MASH \u0625\u0644\u0649 \u062a\u0644\u064a\u0641 \u0627\u0644\u0643\u0628\u062f \u0648\u062a\u0644\u064a\u0641 \u0627\u0644\u0643\u0628\u062f \u0648\u062d\u062a\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0628\u062f\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u0639\u0644\u0649 \u0639\u0643\u0633 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0627\u0644\u0631\u0633\u0648\u0644 (mRNA)\u060c \u0627\u0644\u0630\u064a \u064a\u0634\u0641\u0631 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a\u060c \u062a\u0644\u0639\u0628 ncRNAs \u062f\u0648\u0631\u064b\u0627 \u062a\u0646\u0638\u064a\u0645\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a. \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0634\u0631\u0643\u0629 ncRNAs \u0645\u062d\u062f\u062f\u0629 \u062a\u0634\u0627\u0631\u0643 \u0641\u064a \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u060c \u0628\u0647\u062f\u0641 \u062a\u0639\u062f\u064a\u0644 \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0644\u062a\u062d\u0642\u064a\u0642 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629. \u064a\u064f\u0646\u0638\u0631 \u0625\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0639\u0644\u0649 \u0623\u0646\u0647 \u0637\u0631\u064a\u0642 \u0648\u0627\u0639\u062f \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u062d\u064a\u062b \u0642\u062f \u062a\u0643\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0623\u0642\u0644 \u0641\u0639\u0627\u0644\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u064a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0645\u0631\u0634\u062d \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0634\u0631\u0643\u0629\u060c RES-010\u060c MASH \u0648\u0627\u0644\u0633\u0645\u0646\u0629. \u062a\u0645 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u062a\u0639\u062f\u064a\u0644 ncRNAs \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0644\u0644\u062f\u0647\u0648\u0646 \u0648\u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u060c \u0628\u0647\u062f\u0641 \u062a\u0642\u0644\u064a\u0644 \u062f\u0647\u0648\u0646 \u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628. \u0623\u0638\u0647\u0631 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0634\u062d \u0646\u062a\u0627\u0626\u062c \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u062a\u0633\u062a\u0639\u062f Resalis \u0644\u0644\u062a\u0642\u062f\u0645 \u0628\u0647 \u0625\u0644\u0649 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0643\u0644\u0627 \u0627\u0644\u0645\u0624\u0634\u0631\u064a\u0646. \u0644\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629\u060c \u062d\u0635\u0644\u062a \u0634\u0631\u0643\u0629 Resalis Therapeutics \u0645\u0624\u062e\u0631\u064b\u0627 \u0639\u0644\u0649 11.1 \u0645\u0644\u064a\u0648\u0646 \u062f\u0648\u0644\u0627\u0631 \u0641\u064a \u062c\u0648\u0644\u0629 \u062a\u0645\u0648\u064a\u0644 \u0645\u0646 \u0627\u0644\u0641\u0626\u0629 A.<\/strong><\/div>\n<\/div>\n
\n
\u0633\u064a\u0628\u064a\u0644\u0627 \u0644\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 Sibylla Biotech<\/strong><\/div>\n
\u062a\u0637\u0648\u0631 \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0647\u0630\u0647\u060c \u0627\u0644\u062a\u064a \u064a\u0642\u0639 \u0645\u0642\u0631\u0647\u0627 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0641\u064a \u0645\u064a\u0644\u0627\u0646\u0648 \u0628\u0625\u064a\u0637\u0627\u0644\u064a\u0627\u060c \u0639\u0644\u0627\u062c\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u0627\u0631\u0627\u062a \u0637\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646.<\/strong><\/div>\n
\u062a\u0631\u0643\u0632 \u0646\u0647\u062c \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0644\u0649 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062a\u062d\u0644\u0644 \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644\u0629 \u0644\u0644\u0637\u064a (FIDs)\u060c \u0648\u0647\u064a \u0641\u0626\u0629 \u062c\u062f\u064a\u062f\u0629 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0635\u0645\u0645\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0634\u0648\u0647\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0634\u0627\u0631\u0643 \u0641\u064a \u0623\u0645\u0631\u0627\u0636 \u0645\u062e\u062a\u0644\u0641\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u062a\u0646\u0643\u0633\u064a\u0629.<\/strong><\/div>\n<\/div>\n
\n
\u064a\u062c\u0628 \u0623\u0646 \u062a\u0637\u0648\u0649 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0625\u0644\u0649 \u0623\u0634\u0643\u0627\u0644 \u062b\u0644\u0627\u062b\u064a\u0629 \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0645\u062d\u062f\u062f\u0629 \u0644\u062a\u0639\u0645\u0644 \u0628\u0634\u0643\u0644 \u0635\u062d\u064a\u062d. \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062a\u062d\u0644\u0644 \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644\u0629 \u0644\u0644\u0637\u064a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0634\u0631\u0643\u0629 \u0647\u064a \u062c\u0632\u064a\u0626\u0627\u062a \u0635\u063a\u064a\u0631\u0629 \u062a\u0631\u062a\u0628\u0637 \u0628\u0634\u0643\u0644 \u0627\u0646\u062a\u0642\u0627\u0626\u064a \u0628\u0628\u0639\u0636 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0634\u0648\u0647\u0629 \u0648\u062a\u062b\u0628\u062a\u0647\u0627\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u062d\u0644\u0644\u0647\u0627 \u0628\u0648\u0627\u0633\u0637\u0629 \u0646\u0638\u0627\u0645 \u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u062c\u0648\u062f\u0629 \u0627\u0644\u062e\u0644\u0648\u064a. \u062a\u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0628\u0634\u0643\u0644 \u0641\u0639\u0627\u0644 \u0639\u0644\u0649 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0636\u0627\u0631\u0629\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0648\u0642\u0641 \u062a\u0642\u062f\u0645 \u0627\u0644\u0645\u0631\u0636.<\/strong><\/div>\n<\/div>\n
\n
\u0625\u0646 \u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0634\u0631\u0643\u0629 \u0630\u0627\u062a \u0635\u0644\u0629 \u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u062d\u064a\u062b \u064a\u0644\u0639\u0628 \u0637\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062e\u0627\u0637\u0626 \u062f\u0648\u0631\u064b\u0627 \u062d\u0627\u0633\u0645\u064b\u0627\u060c \u0645\u062b\u0644 \u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u062a\u0646\u0643\u0633\u064a\u0629 \u0645\u062b\u0644 \u0647\u0646\u062a\u0646\u063a\u062a\u0648\u0646 \u0648\u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646.<\/strong><\/div>\n<\/div>\n
\n
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